advanced gastrc cancer
Conditions
Interventions
Group 2:rh-CSF
Sponsors
Liaoning Cancer Hospital and Institute
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. All patients gave written informed consent before any study-related procedure was performed; 2. Pathological or cytological diagnosis is gastric cancer and included patients satisfied the chemotherapy-related essential requirements; 3. Adequate heart,renal,hepatic and cardiac function and non-pregnant or no mental illness; 4. KPS score ranged from 70 to 100; 5. Incidence rate of FN =20%; 6. Primary chemotherapy and TNM stage is IIIa-IIIc (staging by CT, endoscopy, MRI, PET-CT); 7. No metachysis and no applying neutropenia treatment-related drugs such as DMPA,MA,ACTH,no radiation and chemotherapy; 8. WBC>4.0×10^9/L, PMN>2.0×10^9/L, PLT>100×10^9/L before chemotherapy.
Exclusion criteria
Exclusion criteria: 1. Patients are allergic to G-CSF and PEG-rhG-CSF; 2. Patient compliances are bad or refusing to apply G-CSF and PEG-rhG-CSF; 3. If patients had worse bone marrow suppression or infection and needed to other updating WBC; 4. Patients happened untolerable and/or worse reactions even to be life-threatening when using G-CSF and PEG-rhG-CSF; 5. Blood routine was abnormal before chemotherapy; 6. Patients had related-cardiac disease and hepatic and renal function were inadequate; 7. Metachysis and applying neutropenia treatment-related drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neutrophil descent time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Chemotherapy-related delay rate;Chemotherapy-related completion rate;mean hospitalization cost;Perioperative infection rate; | — |
Countries
China
Contacts
Public ContactZhao Yan
Liaoning Cancer Hospital and Institute
Outcome results
None listed