acute hypertriglyceridemia-induced pancreatitis
Conditions
Interventions
Group Insulin:insulin infusion
Group Aphesis:Aphesis
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Adult aged 18 to 80 years old; 2. abdominal pain consistent with AP; 3. serum amylase and / or lipase activity is at least 3 times higher than the normal upper limit; 4. abdominal imaging consistent with AP imaging changes. 5. severe hyperlipidemia "fasting serum TG> 1,000 mg/dL (11.2mmol/L)"; 6. except for other AP causes, such as cholelithiasis, alcohol, drugs and so on.
Exclusion criteria
Exclusion criteria: (1) other etiologies other than hyperlipidemia leading to AP; (2) fasting serum TG less than 1,000 mg / dL (11.2mmol / L) ; (3) acute lipid-induced pancreatitis at the same time combined with other etiologies of acute pancreatitis. (4) the existence of plasma replacement contraindications: serious allergies to plasma, human serum albumin, heparin and others; the existence of mental disorders; unstable heart or cerebral infarction; intracranial hemorrhage or severe cerebral edema associated with hernia. (5) without informed consent, the patient refused to plasma replacement, and other circumstances may bring significant bias.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum TG; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6;IL-8;IL-10;TNF-a;hsCRP;ESR;Amylase;lipase; | — |
Countries
China
Contacts
Public ContactHuadong Zhu
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Outcome results
None listed