Chronic Tic Disorder or Tourette's Syndrome
Conditions
Interventions
Control Group:N/A,
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 25 Years
Inclusion criteria
Inclusion criteria: 1. Patients who fulfilled the diagnosis criteria ofchronic tic disorder or Tourette's syndrome according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition; 2. Patients aged 3-25 years old, no sex limited; 3. YGTSS > 22; 4. Patients diagnosed or acceptted regular treatment for more than one year, but ineffcetive or relapsed; 5. Stop using any kinds of antimicrobial drugs, probiotic, prebiotics, immunosuppressive drugs, high doses of vitamins and other drugs affected intestinal microbes for more than 1 month; 6. Voluntarily participated in the study and signed the informed consent form by a legally acceptable representative or/and the patients.
Exclusion criteria
Exclusion criteria: 1. Patients with an allergy to anesthetics; 2. Patients with organic nervous system diseases or other kinds of diseases seriously impaceted the quality of life; 3. IQ = 70; 4. Patients have a history of abuse of psychosis; 5. treatment follow-up process of children or families can not meet.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Yale Global Tic Severity Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Global Impression-Improvement (CGI-I);Yale-Brown Obsessive Compulsive Scale (CY-BOCS);Conner Parent Symptom Questionnaire;Gastreointestinal Symptom Index;Child Behavior Checklist;adverse effects;Fecal Microbiota Changes;Fecal Metabolites; | — |
Countries
China
Contacts
Public ContactYunsheng Yang
Chinese PLA General Hospital
Outcome results
None listed