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A multicenter, prospective, randomize control study to compare the impact of Letrozole plus Urofollitropin versus mono use of Urofollitropin on live birth rate after intrauterine insemination (IUI)

A multicenter, prospective, randomize control study to compare the impact of Letrozole plus Urofollitropin versus mono use of Urofollitropin on live birth rate after intrauterine insemination (IUI)

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IIR-17011033
Enrollment
Unknown
Registered
2017-03-31
Start date
2017-04-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Interventions

A:Letrozole plus Urofollitropin
B:Urofollitropin

Sponsors

Jiangsu Provincial Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
21 Years to 35 Years

Inclusion criteria

Inclusion criteria: All patients meet the indications for IUI treatment 1. Medical history of infertility 1 year to 5 years; 2. Aged 21-35 years; 3. Double unobstructed oviduct confirmed by hysterosalpingography and/or laparoscope; 4. No history of pelvic inflammation, ectopic pregnancy, and previous IUI or IVF treatment; 5. Normal ovary function (bFSH<10IU/LAFC=7).

Exclusion criteria

Exclusion criteria: 1. Infertility due to pelvic or tubal factor; 2. Contraindications to IUI treatment; 3. Diminished ovarian reserve (BFSH>10IU/LAFC28, Weight>80kg) 5. History of intrauterine adhesion or abnormal morphology of the uterine cavity; 6. Recurrent spontaneous abortion.

Design outcomes

Primary

MeasureTime frame
live birth rate per cycle;

Secondary

MeasureTime frame
Cumulative live birth rate;clinical pregnancy rate per cycle;Cumulative clinical pregnancy rate;Miscarriage rate;Gn dosage and days;number of follicles with diameter =16mm;number of follicles with diameter =14mm;follicle number on hCG day;E2 on hCG day;Endometrium thickness on hCG day;single follicle rate;cycle cancellation rate;

Countries

China

Contacts

Public ContactLiu Jiayin

The First Affiliated Hospital of Nanjing Medical University / Jiangsu Provincial Hospital

872286653@qq.com+86 13851815283

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026