The application value of goal-directed fluid therapy in the patient undergoing one-lung ventilation

Goal-directed fluid therapy using stroke volume variation and cardiac index attenuates lung injury in patients undergoing one-lung ventilation

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IIR-17010884

Enrollment

Unknown

Registered

2017-03-16

Start date

2017-03-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

elective thoracoscopic lobectomy

Interventions

goal-directed fluid therapy group:goal-directed fluid therapy

conventional fluid therapy group:conventional fluid therapy

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Sixty ASA physical status I or II patients of both sexes, aged 30 to 60 years, Preoperative normal pulmonary function,and no received radiotherapy, chemotherapy and immunosuppressive agents, scheduled for elective thoracoscopic lobectomy under OLV. The same type of surgery is operated by the same group of doctors, and written informed consent was obtained from all enrolled patients.

Exclusion criteria

Exclusion criteria: 1. severe liver and kidney dysfunction, coagulation abnormalities and perioperative allogeneic blood; 2. autoimmune disease or immunocompromised patients; 3. cardiovascular adverse reactionsgastrointestinal bleeding in patients after using NSAIDs; 4. high blood pressure, severe heart failure; 5. enoxacin, lomefloxacin, norfloxacin being used; 6. others is unsuitable for selected.

Design outcomes

Primary

Measure	Time frame
hemodynamic;Blood gas analysis;pneumodynamics;Inflammatory cytokines;	—

Secondary

Measure	Time frame
awakening time;the length of hospital stay;	—

Countries

China

Contacts

Public ContactShu Shuhua

Anhui Provincial Hospital (the Affiliated Provincial Hospital of Anhui Medical University)

sshhf@189.cn+86 15375472196

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026