critical illness myopathy
Conditions
Interventions
Nerve growth factor group:mouse nerve growth factor
placebo group:placebo
Sponsors
Department of Neurology, Nanfang Hospital, Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged = 18 years; 2. Adimmted to neurocritical care unit; 3. Predicted duration of intensive care unit stay = 3 days.
Exclusion criteria
Exclusion criteria: 1. Patients with a certain history of peripheral neuropathy or myopathy, or admitted to the ICU probably because of peripheral neuropathy or myopathy, such as Guilllain-Barre syndrome, polymyositis, myasthenia gravis or botulism; 2. Patients with any chronic diseases related to neuromuscular disease, such as chronic renal failure and chronic alcoholism; 3. Patients unable to perform NCS and EMS examination because of any diseases that injure the upper and the lower limps; 4. Patients unsuitable for NCS examination because of implantation of cardiac pacemaker or defibrillator; 5. Patients in an end-stage or who are critically ill with an expected lifetime < 7 days; 6. Patients with malignant tumor and are under anti-tumor therapy; 7. Patients who are pregnant or under the lactation period; 8. Patients with uncontrolled seizure or with status epileptics and large dose of sedative are required; 9. Patients who have used nerve growth factor from any manufactory after the onset of disease; 10. Patients who do not sign the informed consent; 11. Patients who are regarded unsuitable for this study by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| compound muscle action potential (CMAP) level of median nerve and nervus peroneus communis; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of critical illness neuropathy or myopathy;mRS score;duration of mechanical ventilation;length of neurocritical care unit stay;length of hospital stay;incidence of hospital infection;length of antibiotics used;hospital mortality; | — |
Countries
China
Contacts
Public ContactSuyue Pan
Department of Neurology, Nanfang Hospital, Southern Medical University
Outcome results
None listed