coronary artery disease
Conditions
Interventions
Intervention group:Guanxinning Tablet+conventional treatment
Control group:conventional therapy
Sponsors
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients with stable coronary artery disease who have undergone PCI and have began antiplatelet therapy with aspirin alone for at least 1 month after over 12 months dual antiplatelet therapy ( aspirin plus clopidogrel or ticagrelor; (2) diagnosed as TCM pattern of heart blood stasis; (3) aged between 18 to 80 years old regardless of gender; (4) voluntary to participate and providing written informed consents.
Exclusion criteria
Exclusion criteria: 1. patients with heart failure of NYHA IV; 2. Uncontrolled blood pressure, with a systolic blood pressure =180 mmHg or a diastolic blood pressure=100 mmHg, combined with severe cardiopulmonary insufficiency,severe arrythmia,Severe primary hepatic, renal, hematologic, mental disorders or fatal disease like cancer; 3. high bleeding risk,such as history of hemorrage of vital organs (brain or upper gastrointestinal tract) within 6 months,low platelet counts,abnormal coagulation function,currently taking warfarin,etc.; 4. serum level of ALT,AST or Scr >1.5 times upper limit of normal; 5. Allergic constitution,allergic to multiple food or drugs or allergic to the trial drug; 6. Pregnant, planning to pregnant or lactating women; 7. participating another clinical trial within 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| composite major adverse cardiovascular events(cardiovascular death, non-fatal myocardial infarction, stent thrombosis, revascularization, ischemic stroke and rehospitalization due to unstable angina); | — |
Secondary
| Measure | Time frame |
|---|---|
| all-cause mortality;cardiovascular death;non-fatal myocardial infarction;stent thrombosis;revascularization;ischemic stroke;rehospitalization due to unstable angina;nitroglycerin discontinue rate;Seattle Angina Questionnaire;the MOS item short from health survey;cost; | — |
Countries
China
Contacts
Public ContactHao Xu, Rui Gao
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed