diffuse hepatocellular carcinoma
Conditions
Interventions
group A:Stereotactic intensity-modulated radiotherapy combined with Traditional Chinese medicine Kangaisan
group B:Stereotactic intensity-modulated radiotherapy combined with placebo
Sponsors
The Fifth Hospital of Wuhan (Wuhan Cancer Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patient with diffuse hepatocellular carcinoma meet The China diagnose standard of liver cancer; Aged at least 18 years; KPS=70; Bone marrow hematopoietic function tests: WBC=1.5×10^9/L, PLT=100×10^9/L; HGB=10.0 g/dl (HGB=10.0 g/dl under the supportive therapy is accepted), SCR or CCR=60 ml/min, Child-Pugh A or B, ALT<90U/LAST<90U/L, TBil<160umol/L.
Exclusion criteria
Exclusion criteria: Patients were accepted abdominal radiotherapy or potential radiation fields overlap due to radiation therapy; A large number of peritoneal effusion suggested by color ultrasound; intrahepatic metastasis; metastasis in other distant organs; fertile female and male who are not willing to contracept; patients are not suitable to enhance contrast MRI or CT examinations (cardiac pacemaker, allege to enhance contract agents and so forth); unstable angina pectoris and /or chronic congestive heart-failure happened within six months; transmural myocardial infarction happened in six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical benefit rate;survival rate;Karnofsky;gastrointestinal reaction;radiation-induced hepatitis;bone marrow depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Median Survival Time;Alpha-fetoprotein;liver function;QOL-C30;Clinical symptom score; | — |
Countries
China
Contacts
Public ContactLong Zhixiong
The Fifth Hospital of Wuhan (Wuhan Cancer Hospital)
Outcome results
None listed