Helicobacter pylori associated gastritis
Conditions
Interventions
Experiment group A:Omeprazole 20mg Bid+amoxicillin 1g Bid+ clarithromycin 0.5g Bid+ polaprezinc 75mg Bid× 2 weeks
Experiment group B:Omeprazole 20mg Bid+amoxicillin 1g Bid+ clarithromycin 0.5g Bid+ polaprezinc 150mg Bid× 2 weeks
Control group:Omeprazole 20mg Bid+amoxicillin 1g Bid+ clarithromycin 0.5g Bid× 2 weeks
Sponsors
Department of Gastroenterology, Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Ages 18-70 years; 2. Positive C13 or C14 urea breath test; 3. Gastroscopy within 6 months to exclude ulcer, gastric cancer etc.; 4. Penicillin skin test negtive; 5. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Pre-existing antibiotics or bismuth therapy within 4 weeks before enrollment of the present study; 2. Pre-existing PPI therapy within 2 weeks before enrollment of the present study; 3. Severe liver, heart, kidney disease, alcoholism, malignant and other serious diseases; 4. Psychosis, severe neurosis; 5. Allergy to polaprezinc or penicillin; 6. Pregnant or lactating women; 7. Participation in other clinical trials within 3 months before enrollment of the present study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| H.pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| improvement of digestive symptoms including upper abdominal pain, acid reflux, belching, heartburn, bloating, nausea and vomiting; | — |
Countries
China
Contacts
Public ContactJiaming Qian
Department of Gastroenterology, Peking Union Medical College Hospital
Outcome results
None listed