lung cancer
Conditions
Interventions
Therapy group 1:SBRT+TAA-sT immunotherapy
Therapy group 2:SBRT+IMPACT immunotherapy
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technolog
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Histologically or cytologically confirmed diagnosis of none-small cell lung cancer; 2. Clinical stage IV accodring to AJCC Cancer Staging (Version 7); 3. Failure of second-line chemotherapy or targeted therapy; 4. Long diameter of >=2 measurement of disease >1.5 cm; 5. Aged more than 18 years; 6. ECOG performance status 3.5×10^9/L, hemoglobin > 90g/L and platelets > 100×10^9/L; 8. Normal renal function: Creatinine clearance > 60 ml/min; 9. Pulmonary function: (1) FEV1>30%; (2) DLCO>30%; 10. Signed written informed consent.
Exclusion criteria
Exclusion criteria: (1) Previous treatment including chemotherapy, radiotherapy, biological targeted therapy and immunotherapy within 4 weeks; (2) Expected survival time 3s or APTT > 10s; (4) A history of severe allergic reactions; (5) Pregnant and/or breastfeeding. Patients of childbearing potential must have a negative pregnancy test. Effective methods of contraception should be carried out during treatment; (6) Patients with other serious intercurrent illness including unstable angina which would interfere with drug, renal disease, chronic hepatitis, uncontrolled diabetes (fasting blood-glucose > 1.5×ULN), HIV/AIDS, uncontrolled infections and mental disorders; (7) Not suitable to be enrolled in the trial in the opinion of the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overal survival;Progression-free survival;Time to progress;abscopal effect;Circulating tumor cell in peripheral blood;Quality of life; | — |
Countries
China
Contacts
Public ContactYang Kunyu
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed