nasopharyngeal carcinoma
Conditions
Interventions
Exprimental group:target volume base on post-induction chemotherapy
Control group:target volume base on pre-induction chemotherapy
Sponsors
Cancer Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients with newly histologically confirmed non-keratinizing carcinoma (according to WHO histological type); 2. Tumor staged as T3-4/N1-3 (according to the 7th AJCC edition staging system); 3. No evidence of distant metastasis (M0); 4. performance status: KPS>=70; 5. WBC>=4×10^9/L, HGB>=90g/L, PLT>=100×10^9/L; 6. ALT, AST=60 ml/min; 8. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. WHO type keratinizing squamous cell carcinoma or basaloid squamous cell carcinoma; 2. age=60 or <18; 3. palliative therapy; 4. Prior malignancy (except adequatedly treated carcinoma in-situ of the cervix or basal/squamous cell carcinoma of the skin); 5. Patient is pregnant or lactating; 6. Previous chemotherapy or radiotherapy(except non-melanomatous skin cancers outside the intended RT treatment volume); 7. Previous chemotherapy or surgery of nasopharynx and neck; 8. Emotional disturbance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| local recurrence; | — |
Secondary
| Measure | Time frame |
|---|---|
| dose distribution;Survival rate; | — |
Countries
China
Contacts
Public ContactXiaodong Zhu
Cancer Hospital of Guangxi Medical University
Outcome results
None listed