Primary osteoarthritis of knee
Conditions
Interventions
treatment group:Multimodal blood management
control group:standard blood management
Sponsors
Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Adult patients who plan to undergo primary TKA on simultaneous bilateral knee joint with a diagnosis of osteoarthritis or aseptic bone necrosis, but not of rheumatoid arthritis
Exclusion criteria
Exclusion criteria: 1. Allergy to tranexamic acid; 2. Receiving warfarin or heparin; had a history of hemophilia, deep venous thrombosis, pulmonary embolism, or renal impairment; or were pregnant; 3. Patients with any cardiovascular problems (such as myocardiac infarction history, atrial fibrillation, angina); 4. Patients with cerebrovascular conditions (such as previous stroke or vascular surgery history); 5. Patients with thromboembolic disorders, or those exhibiting a deteriorating general condition; 6.a history of transfusion in 1 month; 7. Preoperative use of anticoagulant therapy within five days before surgery, coagulopathy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients who were transfused with allogeneic blood;Amounts of allogeneic blood transfused; | — |
Secondary
| Measure | Time frame |
|---|---|
| Average amounts of blood loss;Complications (myocardial infarction, stroke, deep vein thrombosis, pulmonary embolism, any thrombosis, renal failure): CE + DU (Postoperative Day 5);Active range of motion (pre-operation and post-operative Day 5);Decreased Hb;Calculated blood loss;KSS score (at 6th week after surgery); | — |
Countries
China
Contacts
Public ContactZhu Qingsheng
Department of Orthopaedics, Xijing Hospital, The Fourth Military Medical University
Outcome results
None listed