Prostate cancer
Conditions
Interventions
RP+ADT:Radical prostatectomy+androgen deprivation therapy
ADT:androgen deprivation therapy
RT+ADT:Radical radiotherapy+androgen deprivation therapy
Sponsors
Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
Male
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. male; 2. To be aged 18 Years old or oldder; 3. Histologically confirmed prostate adenocarcinoma; 4. Bone scan, CT, and / or MRI were confirmed as bone metastases in patients with stage M1b, and the number of bone lesions was less than 5; 5. Hormone sensitive prostate cancer ; received endocrine therapy within 6 months of PSA decreased to less than 4ng / ml, serum testosterone level less than 1.7nmol/Lor 50ng/dl and metastasis regression or stability, no new lymph node metastasis and abdominal viscera metastasis; 6. ECOG performance status 0-1; 7. Life expectance longer than 5 years; 8. Subjects volunteered to participate and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. The presence of bone metastases other than visceral metastases; 2. Patients with lymph node metastases outside the pelvic region; 3. Patients with high surgical risk disease cant tolerate surgery: such as severe cardiovascular disease, pulmonary dysfunction; 4. Suffering from severe bleeding tendency or blood coagulation disorders; 5. Laboratory test results were obviously abnormal, such as: AST and ALT is more than 2.0 x normal value upper limit of normal (ULN); White blood cell count less than 2.0x109/L; Hemoglobin less than 7.0g/dL; 6. Life expectance less than 5 years;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-free Survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival;Cancer specific mortality;Disease-specific survival;To the time of occurrence of bone related events;To the time of castration resistant prostate cancer.;Compare health related quality of life; | — |
Countries
China
Contacts
Public ContactFangjian Zhou
Sun Yat-sen University Cancer Center
Outcome results
None listed