Helicobacter pylori Infection
Conditions
Interventions
Weifuchun quadruple regimen:Weifuchun tablets, esomeprazole, amoxicillin and clarithromycin
Bismuth quadruple regimen:Bismuth potassium citrate, esomeprazole, amoxicillin and clarithromycin
Standard triple regimen:Esomeprazole, amoxicillin and clarithromycin
Sponsors
Renji Hospital, School of Medicine, Shanghai Jiao Tong university
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Participants with non-ulcer functional dyspepsia or scarred peptic ulcer disease confirmed by upper endoscopy; 2. H. pylori infection confirmed by RUT, 13C-UBT,culture; 3. Never received treatment for H. pylori infection; 4. Voluntarily participated in the study and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Less than 18 years old; 2. Previous H. pylori eradication therapy; 3. With previous gastric surgery; 4. Severe concomitant cardiovascular, respiratory, renal, hepatic, hematological, neurological, endocrine or psychiatric diseases; 5. Pregnancy or lactation; 6. Allergy to any of the study drugs; 7. Administration of antibiotics, bismuth, antisecretory drugs in 8 weeks prior to inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate of H. pylori; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse event rate;Compliance rate; | — |
Countries
China
Contacts
Public ContactHong Lu
Renji Hospital, School of Medicine, Shanghai Jiao Tong university
Outcome results
None listed