cirrhosis with esophageal varices
Conditions
Interventions
ligation alone group:undergoing regular ligation therapy until the obliteration of varice
???????????=0.6cm??????????????:undergoing regular sclerotherapy with diameter of varices=0.6cm after ligation until the obliteration of varices
Sponsors
The first affiliated hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Consecutive patients with decompensated cirrhosis and esophageal varices, with the age between 18-65 years old; 2. Patients underwent endoscopic varices ligation therapy within 1 year, with current diameter of esophageal varices<=0.6cm; 3. All the enrolled patients signed informed consent.
Exclusion criteria
Exclusion criteria: 1. With liver cancer (>stage B in Barcelona Clinic Liver Cancer staging classification) or other malignancy; 2. With gastric varices or other ectopic varices; 3. With severe illness in heart, brain, lung or kidney, such as stroke, uremia, acute coronary syndrome, respiratory failure or type I hepatorenal syndrome; 4. No tolerance to endoscopy; 5. Transjugular intrahepatic portosystemic stent shunt or surgery before entry; 6. Total bilirubin>170umol/L or Child-Pugh score>13; 7. Without cirrhosis; 8. Use of sclerotherapy or cyanoacrylate 1 year before entry.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time to esophageal variceal recurrence; | — |
Secondary
| Measure | Time frame |
|---|---|
| re-bleeding rate after 6 wks and 1 year of index endoscopic therapy;mortality after 6 wks and 1 year of index endoscopic therapy;The time to esophageal variceal obliteration;The number of endoscopic therapy sessions until the obliteration of varices; | — |
Countries
China
Contacts
Public ContactAnjiang Wang
Outcome results
None listed