Hemiplegic hand after central neurologic injury
Conditions
Interventions
Peripheral nerve rewiring surgery group:Peripheral nerve rewiring surgery and rehabilitation therapies
Control group:Rehabilitation therapies
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
12 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Spastic hemiplegia following different causes of central neurologic injuries (CNIs), such as stroke, traumatic brain injury, cerebral palsy, majorly presenting difficulty in hand-open; 2. With normal mental and linguistic functions preserved; 3. Aged 12-45 years old, no limit of gender; 4. The patients had received regular rehabilitation therapies for at least 5 years and ceased improving in the paralyzed hand; 5. The patients (or their parents if the patients were underage) were willing to receive surgeries to achieve further functional improvement; 6. Brain MRI scans verify that central neurologic injury only involves the hemispheres contralateral to the paralyzed hand; 7. The paralyzed hand was controlled by the ipsilesional hemisphere exclusively, indicated by the transcranial magnetic stimulation (TMS).
Exclusion criteria
Exclusion criteria: 1. With severe systemic diseases such as diabetes mellitus, cardiopulmonary diseases that were unable to tolerate the surgery; 2. For personal reasons of patients or the family members urge termination of surgery; 3. Patients who were psychologically or mentally abnormal; 4. Patients who mainly present ankyloses of joints; 5. With poor muscle strength in the paralyzed hand; 6. With severe fixed contracture or joint deformity); 7. Mental retardation or poor learning and communicating capacity (relative contraindication).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Scale;Modified Ashworth Scale;Muscle Power;Tactile threshold;Range of motion;Peripheral nerve conducting test;fMRI;Transcranial magnetic stimulation; | — |
Countries
China
Contacts
Public ContactWen-Dong Xu
Outcome results
None listed