Tumor
Conditions
Interventions
Parallel control group:50ml normal saline cisplatin 60mg + dexamethasone 10 mg intraperitoneal treatment
Experimental group:tumor-derived cells vesicles wrap methotrexate intraperitoneal treatment
Sponsors
Tianjin Nankai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) by pathology or cytology diagnosed as malignant, abdominal B ultrasound or CT diagnosis ascites; (2) Smooth vital signs, KPS (Karnofsky) >=60 points; (3) Aged 18-70 years; (4) normal bone marrow function, no bleeding tendency (INR =90g/L, WBC> 4.0*10^9/L (NEU>=1.5*10^9/L), PLT>=100*10^9/L; (5) The liver function: total bilirubin =60mL/min; (7) with normal ECG, blood sugar levels were normal; (8) patients or their families agreed to participate in the study, and informed consent; (9) No other serious heart and lung diseases.
Exclusion criteria
Exclusion criteria: (1) breast-feeding, pregnant or are preparing to pregnant women; (2) allergies and multiple drug allergies; (3) has a serious heart, major organs lungs, liver and kidney dysfunction, such as decompensated heart, lung, kidney, liver dysfunction, failure or poor glycemic control who can not tolerate chemotherapy; (4) complicated by severe infection; (5) there is cognitive dysfunction, the researchers determined that patients undergoing chemotherapy or with poor compliance; (6) persons participating in other clinical trials within three months; (7) The researchers believe that those who are unsuitable for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Efficacy of Ascites; | — |
Secondary
| Measure | Time frame |
|---|---|
| vital signs;Quality of Life;Survival;Ascites routine;Ascites biochemical;Ascites tumor markers;Blood tumor markers; | — |
Countries
China
Contacts
Public ContactHui Zhang
Outcome results
None listed