Effect of dexmedetomidine on postoperative delirium and cognitive dysfunction and the related factors in elderly gastrointestinal surgery patients

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-IIR-16007689

Enrollment

Unknown

Registered

2016-01-01

Start date

2016-01-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative delirium and cognitive dysfunction

Interventions

Dex group:a loading dosage of dexmedetomidine (0.8 ug/Kg) was infused introvenously 10 min after induction and followed continously at 0.3 ug/Kg/h till 30 min before the ending of surgery

Saline group:same dosage of saline

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: AGE>=65 patients for gastrointestinal surgery, ASA I-III

Exclusion criteria

Exclusion criteria: eliminate cognitive dysfunction, heart, cerebral vascular accident, severe hypertension, malignant arrhythmia, organ disfuction, long-term use of sedative drugs

Design outcomes

Primary

Measure	Time frame
incidence of POD and POCD;	—

Secondary

Measure	Time frame
IL-6;TNF-alpha;NSE;S100B;cortisol;	—

Countries

China

Contacts

Public ContactBao Fangping

Baofp.kelly@163.com+86 13958105226

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026