myocardial damage
Conditions
Interventions
Group 1:0.05µg/kg
Group 2:0.05µg/kg
Group 3:0.5µg/kg
Group 4:2.0µg/kg
Group 5:5.0µg/kg
Group 6:12.5µg/kg
Group 7:25µg/kg
Sponsors
Beijing Shijitan Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1) Chinese healthy subjectshalf males and half females; 2) Aged from 18 to 50 years old; 3) Weight =50 kg, BMI range from 19 to 28kg/m2[BMI=weight/height2]; 4) Good healthy, withoutcardiac, liver, kidney, gastrointestinal tract, immune system, nervous system mental disorderor metabolic abnormalities, without a family history of tumor; 5) Medical history, physical examination, laboratory examinationor other related examinationresults are normal or abnormal but investigator estimate the result is No clinical significance; 6) Subject owns the ability to communicate with hospital staffs and comply with the relevant hospital management regulations; 7) Subject is Able to communicate with theinvestigators, understand and comply with trial requirements; 8) Voluntarily signed informed consent.
Exclusion criteria
Exclusion criteria: 1) Physical examination, Vital signs test laboratory examinationElectrocardiogramresultisabnormaland investigator estimate the result is clinical significance; 2) Active hepatitis B or hepatitis C patients, hepatitis B virus carriers; 3) HIV antibody test positive or syphilis spiral antibody test positive; 4) ADA test positive; 5) Smoking is more than five cigarettes per dayalcohol intake (1 unit = 12 ounces or 360 mL of beer, 5 ounces or 150 mL of white wine, 1.5 ounces or 45 mL of distilled liquor) for 3 months per day for more than 5 persons per day, suspected or indeed having a history of drug abuse Or alcohol test positive; 6) Participated in a drug trial or used in this test drugs in three months; 7) Any other drugs have been used within two weeks before the start of the trial; 8) There is a significant history of allergic reactions, especially drugs, protein preparations, biological products, allergic history, especially for rh-Tß4 or any of the ingredients allergies; 9) Blood donation or blood loss was equal to or more than 400 mL within three months of the trial; 10) Pregnant or breastfeeding women, or women who are pregnant and may not have an acceptable contraceptive method, or who have a positive pregnancy test and who have not taken effective contraceptive measures or their spouse plan within six months of birth; 11) Can not tolerate vein blood collection; 12) It is not guaranteed to ban smoking and ban on grapefruit juice or any alcohol and xanthine-containing foods and beverages (including chocolate, tea, coffee, cola, etc.) from 48 hours before the last administration to the last blood; 13) The investigator judged that the subject was unable to complete the study or that the subject was involved in other situations that could cause harm in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood Pressure;Pulse;Respiration;ECG;Temperature;Blood Routine Examination;Routine Urine Examination;Blood Biochemical; | — |
Countries
China
Contacts
Public ContactXinghe Wang
Beijing Shijitan Hospital Capital Medical University
Outcome results
None listed