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Correlation between gut microbiota metabolite TMAO and sevrity of coronary artery disease and effects of ezetimibe on plasma TMAO levels

Correlation between gut microbiota metabolite TMAO and sevrity of coronary artery disease and effects of ezetimibe on plasma TMAO levels

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-ICR-15007290
Enrollment
Unknown
Registered
2015-10-27
Start date
2015-11-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary heart atherosclerotic disease

Interventions

simvastatin group:the patients were treated by simvastatin 20mg/d
ezetimibe group:the patients were treated by ezetimibe 10mg/d
ezetimibe+simvastatin group:the patients were treated by ezetimibe 10mg/d and simvastatin 20mg/d

Sponsors

Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) between the ages of 18-80 years old, male or female; 2) Since November 2015 at the Shanghai Jiaotong University Xinhua Hospital hospitalized due to coronary heart disease; 3) subjects to communicate smoothly with the doctor; 4) voluntary test subjects, and signed informed consent.

Exclusion criteria

Exclusion criteria: 1) older than 80 years of age or less than 18 years old, admission merger trauma, infection system Disease, past or present time admission was found with severe hepatic dysfunction, merge connective tissue disease, evil tumors or clinical and angiographic data incomplete information; 2) The researchers believe that this study can not be completed patients, or patients with poor compliance; 3) the test subjects known drug allergies or intolerance; 4) pregnancy, lactation female patients.

Design outcomes

Primary

MeasureTime frame
Trimethylamine-N-oxide;Uric acid;High-sensitivity C-reactive protein;Lipid;Glycated hemoglobin;Left ventricular ejection fraction;

Countries

CHINA

Contacts

Public ContactZhang Yachen
hongwu2013@126.com+86 18321836470

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026