Atrial fibrillation
Conditions
Interventions
One:CPVI+CTI+Substrate homogenerization in the LA
Two:CPVI+CTI
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients with symptomatic persistent AF; Persistent AF will be defined as a sustained episode lasting > 7 days and less than 3 years; AF refractory or intolerant to at least1 class I or III antiarrhythmic medication; Patients age is18-75 years; Males or females; Patients signed the written informed consent for the study.
Exclusion criteria
Exclusion criteria: Patients with thromboemboli or tumor in LAA or LA (TEE or MSCT); Patients with left atrial size >=50 mm (2D echocardiography, parasternal long-axis view); Patients with atrial fibrillation because of reversal reason; Patients with cardiac operation history; Patients with previous radiofrequency ablation; Patients are allergic to antiarrythmic medications, anticoagulation drugs, adenosine, or isoprenaline; Patients with severe lung disease; Patients with stent implantation because of myocardial infarction or coronary heart disease; Patients are going to accept cardiac transplantation in recent 12 months; Patients in the acute phase of ischemic stroke; Patients with PLT count less than 80*10^9/L, or with contraindications to systemic anticoagulation with heparin or coumadin or a direct thrombin inhibitor; Patients with severe structural cardiac disease (medium or severe mitral regurgitation, DCM, HCM, other severe valvular heart diseases); Patients with abnormal thyroid function; Patients with severe liver or renal dysfunction ( AST or ALT more than 3 fold of upper limit value; the SCr >3.5mg/dl or Ccr < 30 ml/min); Patients who are in the period of pregnant; Patients with psychosis; Patients with life expectancy < 24 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SR at 0.5, 1, 2 years after ablation respectively;cardiac tamponade; | — |
Countries
China
Contacts
Public ContactFengxiang Zhang
Outcome results
None listed