Alveolar Cleft
Conditions
Interventions
experiment group:uto bone marrow concentrates combined with beta-TCP graft
Sponsors
Plastic Surgery Hospital, Chinsese Academy of Medical Sciences & Peking Union Medical
Eligibility
Sex/Gender
All
Age
8 Years to 27 Years
Inclusion criteria
Inclusion criteria: 1) 10-40 year old male or female patients with bone defect in non-load-bearing area; 2) The defects were in the range of 1-3cm. (Craniofacial bone, jaw bone defects and deformities); 3) Patients and their families voluntarily underwent surgery, postoperative radiological examinations, follow-up and postoperative rehabilitation; 4) Patients and their families need to personally read, understand and sign the relevant voluntary informed consent.
Exclusion criteria
Exclusion criteria: 1) Bone defects larger than 3cm or bone defects in weight-bearing site; 2) Patients with obvious abnormality in routine examination; 3) The heart, lungs, brain, kidneys and other vital organ function or hematopoietic function is severely impaired; 4) Patients with obvious malnutrition; 5) Patients with mental and neurological disorders that can not follow instructions of doctors; 6) Recipient site have extensive scarring or poor blood supply caused by extensive radiotherapy or surgery or multiple trauma; 7) Patients received BMP growth factors or other bone growth promoting factor therapy; 8) Patients with a history of metabolic disease that may affect bone regeneration (such as osteoporosis, osteomalacia); 9) Patients received radiotherapy, chemotherapy, immunosuppressive or anticoagulant therapy recently; 10) Patients with systemic or local infection; 11) Patients with allergic constitution or allergic to drugs, regents or materials (TCP) used in the trial; 12) Patients with alcohol or addictive drugs dependence; 13) Patients participating in other clinical study currently.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bone formation;continuity of alveolar bone; | — |
Secondary
| Measure | Time frame |
|---|---|
| bone density;donor site damage; | — |
Countries
China
Contacts
Public ContactYilin Cao
Outcome results
None listed