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Topical VS intravenous administration of tranexamic acid in posterior thoracolumbar spinal internal fixation operation: a double-blind randomized controlled study

Topical VS intravenous administration of tranexamic acid in posterior thoracolumbar spinal internal fixation operation: a double-blind randomized controlled study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-ICR-15006037
Enrollment
Unknown
Registered
2015-01-26
Start date
2015-02-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal diseases

Interventions

intravenous group:intravenous tranexamic acid (10mg/Kg) and topical saline (50ml) application
topical group:intravenous saline (100ml) and topical tranexamic acid (10mg/Kg) application
control group:administrate saline both intravenously (100ml) and topically (50ml)

Sponsors

The Military General Hospital of Chengdu,PLA
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: The patients who need to undergo posterior thoracolumbar spinal open internal fixation operation s; between 18-70 years old.

Exclusion criteria

Exclusion criteria: allergy to TXA; hemoglobin <110g/L(female)or <120g/L (male); platelets<150000 mm3; coagulation dysfunction; receiving antiplatelet or anticoagulant therapy; thrombosis embolism history; hypercoagulable state; renal dysfunction; hepatic insufficiency.

Design outcomes

Primary

MeasureTime frame
The volume of blood loss during operation;The volume of drainage postoperative;The volume of blood transfusion;Hemoglobin;Fibrinogen;D- dimer;INR;PT;APTT;—

Countries

China

Contacts

Public ContactPan Xianming
Panxianming@medmail.com.cn+86 13981815943

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 25, 2026