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Infant Flow bi-level nasal positive airway pressure (BiPAP) vs. Infant Flow nasal continuous positive airway pressure (CPAP) in preterm infants less than 1500g with respiratory distress syndrome following INSURE treatment: a multicenter randomised controlled trial(RCT)

Infant Flow bi-level nasal positive airway pressure (BiPAP) vs. Infant Flow nasal continuous positive airway pressure (CPAP) in preterm infants less than 1500g with respiratory distress syndrome following INSURE treatment: a multicenter randomised controlled trial(RCT)

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-ICR-15005879
Enrollment
Unknown
Registered
2015-01-24
Start date
2015-02-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bronchopulmonary dysplasia

Interventions

1:SiPAP
2:CPAP

Sponsors

Department of Neonatology, Tongji Hospital, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Infants of birth weight less than 1500g, inborn, affected by RDS following INSURE treatment, were considered eligible in Tongji Hospital and Xiangyang Central Hospital. RDS was diagnosed within four hour of life on radiological and clinical criteria. The RDS diagnosis was based on the classic symptoms such as the need for oxygen supplement, tachypnea, retraction and grunting. RDS was confirmed by typical radiological pattern with decreased lung expansion with reticulogranular pattern and air bronchograms.

Exclusion criteria

Exclusion criteria: Infants with lethal congenital anomalies, congenital abnormalities of the upper airway tract were excluded.

Design outcomes

Primary

MeasureTime frame
BPD;sustained extubation for 7 days;physical growth, lung function and the neurological examination results at 2 years of age;

Countries

China

Contacts

Public ContactRong Zhihui
rongzhihui53@163.com+86 13871530925

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026