Acquired Immunodeficiency Disease
Conditions
Interventions
expeiment group:HIV-specific T cells immunotherapy
control :adoptive immunotherapy off
Sponsors
Beijing You'an Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age, 18 to 60 years; 2. HIV antibody positive; 3. HLA-A2 positive; 4. On stable ART for more than 6 months; 5. Plasma HIV viral load less than 50 copies/ml; CD4+ T cell count more than 350/ul; 6. Comprehensive medical examination without severe liver, kidney damage; 7. Hgb more tha at least 120g/L (male), more than at lest 110 g/L(femal); Neutrophils absolute value (ANC) more than at least 2*10^9/L; Platelet more than at least 100*10^9/L; Creatinine less than at least 100umol/L; Aspertate aminotransferase (AST) and third transaminase (ALT) less than 2.5xULN; 8. Subjects should completely understand the purpose, properties, methods, and possible response of the study; 9. Willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Plasma HIV viral load more than 50copies/ml; 2. With severe opportunistic infection or tumor; 3. AST or ALT more than 3xULN, Creatinine more than normal; 4. With severe chronic diseases, metabolic diseases (such as diabetes), neurological and psychiatric diseases; 5. With pancreatitis; 6. Pregnant women or women that plan to get pregnant during the study period; 7. Lower possibility into groups (such as the weak, poor adherence); 8. Allergic constitution; 9. With alcohol or drug abuse history; 10. With any other drug trial (except traditional Chinese medicine) in 3 months; 11. Cannot recipients for intravenous injection; 12. Other factors that not fit into the test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD4 cell counts; | — |
Countries
China
Contacts
Public ContactYonghong Zhang
Outcome results
None listed