The protective effect of hydrogen gas against myocardial ischemia-reperfusion injury in patient undergoing coronary artery bypass surgery with cardiopulmonary bypass

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-ICR-14005495

Enrollment

Unknown

Registered

2014-11-09

Start date

2014-12-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary arteriosclerotic heart disease

Interventions

CPB group :80% oxygen is supplied to the blood by cardiopulmonary bypass machine during CPB

CPB +2%H2 group:the combination of 2% hydrogen gas and 80% oxygen is supplied to the blood by cardiopulmonary bypass machine for 1 hour and then only 80% oxygen is supplied during CPB

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. The patients undergoing coronary artery bypass surgery with cardiopulmonary bypass operated by the same surgeons; 2. ASA: II-IV; 3. NYHA: II-III; 4. Age: 40-70 years, sex unlimited; 5. The patients who have fully understood the study and signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. History of cardiac surgery or congenital heart disease; 2. Diabetes mellitus;severe hypertension;severe liver dysfunction or kidney dysfunction;history of nervous systeym disease, mental or coagulaton dysfunction; 3. Obesity (BMI greater than 30); 4. History of long-term taking antibiotics or glucocorticoids;history of taking antibiotics, glucocorticoids or free radical scavenger at 1 month preoperatively; 5. Cardiac failure (LVEF less than 30%);severe arrhythmia preoperatively; 6. Combined with inflammatory reponse preopertively (infection, active arthritis or malignant tumor); 7. The patient have involved in clinical tests about other drugs for nearly 4 weeks; 8. The operation time: longer than 8 hours or shoter than 4 hours; the CPB time: longer than 3 hours or shoter than 1 hours; the heart is completely stopped during operation; two or more times CPB in operation; the clinical data is incomplete; 9. The researchers don't think there is any suitable for inclusion for any reason.

Design outcomes

Primary

Measure	Time frame
Troponin I;Creative kinase-MB;	—

Secondary

Measure	Time frame
The concentration of hydrogen gas;Interleukin-6;High mobility group box 1;Superoxide dismutase;Malondialdehyde;NF-kB;	—

Countries

China

Contacts

Public ContactYonghao Yu

yuyonghao@126.com+86 13920590099

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026