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A randomized controlled clinical trial of electroacupuncture inhibiting chronification of the acute pain of knee osteoarthritis

Neurobiological mechanisms of electroacupuncture inhibiting chronification of acute pain by endocannabinoid system

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-ICR-14005411
Enrollment
Unknown
Registered
2014-10-31
Start date
2014-09-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

strong electroacupuncture (EA) group:The patients receive EA on the ipsilateral "Neixiyan" (EX-LE5), "Dubi" (ST35)," "Liangqiu" (ST34) and "Xuehai" (SP10) with high-intensity current (Stimulation inde
weak EA group:Intervention: Acupoints of weak EA were as same as strong EA group, and patients receives low-intensity current (Stimulation index: direct current, continuous wave, frequency of 2Hz, pul
Sham EA group:Intervention: For sham control, fine needles were inserted superficially into the sites 1cm lateral to above four points with low-intensity current (Stimulation index: direct current, co

Sponsors

School of basic medicine, Tongji medical college, Huazhong university of science and technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 80 Years

Inclusion criteria

Inclusion criteria: The American College of Rheumatism (ACR) formulated the clinical criteria of OA at 2001. Clinical OA of the knee is defined as knee pain and at least three out of seven of the following criteria: to be aged older than 50 years, morning stiffness less than 30 min, crepitus, bony enlargement, bony tenderness, no palpable warmth, and line with radiological osteophyte.

Exclusion criteria

Exclusion criteria: 1. Patients has adverse reactions to acupuncture or unwilling to accept acupuncture treatment; 2. Patients conform to the inclusion criteria, but didn't follow prescribed treatment, whose curative effect were unable to be judged, or patients with incomplete information which may interfere with efficacy or safety of judge; 3. Patients with accompanying severe cardiovascular, cerebral, hepatic, renal, hemopoietic diseases; 4. Patients with inflammatory arthritis such as rheumatoid arthritis, gouty arthritis, etc., or other diseases that may affect the condition of the knees; 5. Pregnant patients or women need fertilization, women in lactation period; 6. Patients with mental diseases.

Design outcomes

Primary

MeasureTime frame
Visual analogue scale (VAS);Diffuse noxious inhibitory controls (DNIC) function;

Secondary

MeasureTime frame
Emotional scale (ES);Present Pain Intensity (PPI);Western Ontario and McMaster Universities Osteoarthritis (WOMAC);Numerical pain rating scale (NPRS);

Countries

China

Contacts

Public ContactLi Man

Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

liman73@mails.tjmu.edu.cn+86 27 83692630

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 17, 2026