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Auricular reconstruction using in vitro engineered human-ear-shaped cartilage regenerated with microtia chondrocytes

in vitro regeneration of tissue engineered human-ear-shaped cartilage and its clinical translation

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-ICN-14005469
Enrollment
Unknown
Registered
2014-10-16
Start date
1990-01-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

microtia

Interventions

engineered cartilage repair group:repair with the engineered human-ear-shaped cartil

Sponsors

Shanghai 9th People's Hospital/ National Tissue Engineering Center of China / Plastic Surgery Hospital, Chinese Academy of Medical Science
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1) The first diagnosis must comply with ICD-10: Q17.20 for patients with microtia; 2) 6-50 years of age; 3) Healthy, with no history of systemic disease; 4) Have microtia cartilage, with I or II of microtia indexing level;

Exclusion criteria

Exclusion criteria: 1) Poor state of health; 2) Local hormone therapy within 3 months; 3) Blood disease or bleeding tendency; 4) Drug addiction (including drugs, anesthetic, and alcohol addiction); 5) Allergic cicatricial physical or physical persons; 6) Infected with contagious virus; 7) Fever, colds or other symptoms of infection for nearly a month; 8) Women in pregnancy or lactation, or plan to get pregnant within one year after initial registration; 9) Psychological disorder, cannot coordinate with treatment; 10) Poor development of craniofacial facial nerve; 11) Major organ malfunction.

Design outcomes

Primary

MeasureTime frame
specialized examination of microtia ear;specialized examination of normal ear;facial development;facial nerve development;imaging;chemistry tests;

Countries

China

Contacts

Public ContactYilin Cao
yilincao@yahoo.com+86 13701802351

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 7, 2026