myocardial ischemic reperfusion injury
Conditions
Interventions
Group plopofol:Combination of propofol and Sevoflurane
Group Sevoflurane:Sevoflurane
Sponsors
Affiliated Hospital of Guangdong Medical College
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 60 volunteer patients, 20-70 years of age, NYHA grade II to III, ASA grade II to III, at a university hospital undergoing heart valve replacement.
Exclusion criteria
Exclusion criteria: 1. previous coronary or valvular heart surgery; 2. combined operations; 3. preoperative myocardial infarction within the last 4 weeks or ongoing myocardial infarction; 4. poor ventricular function (ejection fraction 0.30); 5. preoperative haemodynamic instability with the need for medical or mechanical support; 6. severe hepatic disease; 7. renal insufficiency; 8. severe chronic obstructive pulmonary disease [FEV1 (forced expiratory volume in1 s) <0. 5litres]; 9. severe coagulation abnormalities, and 10. history of neurological disturbances.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hemodynamics;cTnT;TNF-a;Endothelial microparticles; | — |
Countries
China
Contacts
Public ContactLiang-qing zhang
Outcome results
None listed