Evaluation study on screening of upper gastrointestinal cancer in China: a randomized controlled trial

Conditions

upper gastrointestinal cancer

Xia C, Li H, Xu Y, Guo G, Yu X, Wang W, Dai S, Dai C, Zhu Y, Jiang K, Zhang Z, Hu J, Song G, Chen C, Xiao H, Chen Y, Song T, Yan S, Song B, He Y, Zhou J, Zhang S, Chen W.

2024-12-187 citations

10.1053/j.gastro.2024.11.025

A cluster randomized controlled trial to evaluate the efficacy of esophageal and gastric cancer screening in mortality reduction in a non-high-incidence area: methodology and initial results

Xiaoyang Wang, Shuzheng Liu, Huifang Xu, Yin Liu, Hong Wang et al. (16 authors)

Annals of Translational Medicine2022-09-012 citations

10.21037/atm-22-4052

Initial results from a multi-center population-based cluster randomized trial of esophageal and gastric cancer screening in China.

Zeng H, Sun K, Cao M, Zheng R, Sun X, Liu S, Zhang Z, Liu Y, Guo G, Song G, Zhu Y, Wu X, Song B, Liao X, Chen Y, Song M, Giovannucci E, Zhuang G, Wei W, Chen W, He J.

2020-11-2439 citations

10.1186/s12876-020-01517-3

Evaluating efficacy of screening for upper gastrointestinal cancer in China: a study protocol for a randomized controlled trial

Wanqing Chen, Hongmei Zeng, Ru Chen, Ruyi Xia, Zhixun Yang et al. (11 authors)

Chinese Journal of Cancer Research2017-01-0137 citations

10.21147/j.issn.1000-9604.2017.04.02

Interventions

1:endoscopic examination

2:NA

Eligibility

Sex/Gender

All

Age

40 Years to 69 Years

Inclusion criteria

Inclusion criteria: A total of seven cities/counties would be selected as the screening centers, covering areas with high incidence of upper gastrointestinal cancer and middle/low incidence rates. Multi-center cluster based randomization would be used. Cases and controls will be 1:1 matched. In areas with high incidence of upper gastrointestinal cancer, 60 000 subjects will be enrolled. In areas with middle/low incidence of upper gastrointestinal cancer, 80 000 subjects will be enrolled. The areas with high risk of uppergastrointestinal cancer are located at: Linzhou County of Henan Province, Cixian County of Hebei Province, Wuwei County of Gansu Province. The areas with middle/low risk of uppergastrointestinal cancer are located at: Sheyang County of Jiangsu Province, Luoshan County of Henan Province, Harbin City of Heilongjiang Province. The inclusion criteria includes: local residents aged 40-69, no history of cancer, no history of endoscopic examination in the latest 3 years, willing to accept endoscopic examination.

Exclusion criteria

Exclusion criteria: 1. Subjects with history of cancer or severe diseases who are tolerate endoscopic examination; 2. Subjects who are not willing to take endoscopic examination; 3. Men and women who at the time of randomization are 69 years of age; 4. Individuals currently undergoing treatment for cancer; 5. Individuals who had uppergastrointestinal endoscope in the past three years; 6. Individuals who are unwilling to sign the consent form.

Design outcomes

Primary

Measure	Time frame
mortality rate;	—

Secondary

Measure	Time frame
detection rate;incidence rate;survival rate;stage;Cost benefit ratio;Cost-Effectiveness Ratio;QUALITY ADJUSTED LIFE YEAR;DISABILITY ADJUSTED LIFE YEAR;	—

Countries

China

Contacts

Public ContactWANQING CHEN

NATIONAL CANCER CENTER OF CHINA

chenwq@cicams.ac.cn+86 10 87787039

Outcome results

None listed