pain
Conditions
Interventions
Han, Uyghur, Kazakh
Hui pepole:no intervention
Sponsors
Department of Anesthesiology of The First Affiliated Hospital of Shihezi University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Part I: the study of pain threshold of different ethnic groups in multi-center and large samples Inclusion criteria: The subjects' parents, grandparents were all married within their own ethnic groups. No history of mental illness and family mental illness; No long-term use of cortisol, sedative and analgesic drug history; No history of chronic pain; No long history of opioid drug use; No history of alcoholism; The kidneys, liver, lungs and heart function were not abnormal; Women have no menopause;Age 18 to 45;Healthy adults have no history of basic diseases. Part ii: studies on pain genetics of different ethnic groups in multi-center and large samples Inclusion criteria: The subjects' parents, grandparents were all married within their own ethnic groups.No history of mental illness and family mental illness;No long-term use of cortisol, sedative and analgesic drug history; No history of chronic pain; No long history of opioid drug use; No history of basic diseases; The kidneys, liver, lungs and heart function were not abnormal; Women have no menopause; No history of smoking and drinking; All patients selected were diagnosed with uterine fibroids based on the history, symptoms, signs, physical examination and B ultrasound.Age 20 to 45 years old, BMI18.5 ~ 29.5 kg/m2, ASA I or II level.
Exclusion criteria
Exclusion criteria: Part I: the study of pain threshold of different ethnic groups in multi-center and large samples Exclusion criteria: Permanent resident of non-xinjiang region; Single parent family, orphans; During pregnancy, menstruation women; The upper extremity fracture, joint trauma history, development and the feeling of the abnormality;The upper extremity skin has broken, infection, the feeling is different; Noncooperationist; The author and the subjects voluntarily requested the temporary withdrawal; An allergic person. Part ii: studies on pain genetics of different ethnic groups in multi-center and large samples Exclusion criteria: Permanent resident of non-xinjiang region; Single parent family, orphans; During pregnancy, menstruation women;The upper extremity fracture, joint trauma history, development and the feeling of the abnormality; The upper extremity skin has broken, infection, the feeling is different; Noncooperationist; The author and the subjects voluntarily requested the temporary withdrawal; An allergic person; Patients with uterine membrane cancer, endometrial malignant lesions, cervical lesions, etc.; Severe endosurgical complications and surgical contraindications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain threshold;beta-endorphin;OPRM1 A118G, COMT gene rs6269, rs4633, rs4818, and rs4680, CYP3A gene CYP3A4 * 1, CYP3A5 * 3; | — |
Countries
China
Contacts
Public ContactWang Sheng
Department of Anesthesiology of The First Affiliated Hospital of Shihezi University Medical School
Outcome results
None listed