esophageal dysmotility
Conditions
Interventions
NA:NA
Sponsors
Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science andTechnology,Wuhan, Hubei, China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age: 18-65 years; 2.BMI: 18.523.9, height: 155cm-178cm; 3.No persistent gastrointestinal symptoms in recent 3 months, andno acid reflux, regurgitation, heartburn andchest pain in recent 1 month; 4.No esophageal mucosa break in the endoscopy examination, andthe upper GI tract seems normal; 5.No prokinetics in recent 1 month; 6.Agree to attend this study andsign informed consent.
Exclusion criteria
Exclusion criteria: 1.Past history of gastrointestinal structural diseases; 2.Campylorrachis scoliosa andchest wall deformity; 3.History of chest andabdomen operation except Cesarean section andoperation for appendicitis; 4.Any diseases affecting GI tract motility, for example, hypertension, DM, renal function failure, thyroid diseases, connective diseases andmental disorders; 5.Abnormalities of lab tests: fasting blood sugar, hepatic enzyme(ALT,AST), renal function(BUN,Cr) andECG; 6.Pregnant andbreast feeding women; 7.People who attends other clinic trials in resent 3 months; 8.Refuse to assign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LES midpoint(from nares, cm);upper EGJ margin (from nares, cm);lower EGJ margin (from nares, cm);EGJ length (cm);esophageal body length (cm);PIP (from nares, cm);intra-abdominal LES length (cm);UES midpoint (from nares, cm);upper UES margin (from nares, cm);lower UES margin (from nares, cm);UES length (cm);Mean basal pressure of UES midpoint (mmHg);Mean basal pressure of UES zone (mmHg);maximal pressure of UES zone(mmHg);Inspiratory UES pressure(mmHg);Expiratory UES pressure (mmHg);Basal LES pressure(respiratory minimum) (mmHg);Basal LES pressure(respiratory mean)(mmHg);Inspiratory augmentation(mmHg);EGJ-CI(mmHg.s.cm);LES-PI (mmHg.s.cm);UES residual pressure (mmHg);UES relaxation duration (ms);UES time-to-nadir(ms);UES recovery time(ms);4s IRP of EGJ (mmHg);LES relaxation time (s);IBP (@ LESR) (mmHg);IBP (average maximum) (mmHg);Proximal Maximal pressure (mmHg);Distal Maximal pressure(mmHg);Wave amplitude (mean, 3.0 & 7.0 above LES) (mm Hg);Wave amplitude (@11.0 above LES) (mm Hg);Wave amplitude (@7.0 above LES) (sec);Wave amplitude (@3.0 above LES) (sec);Proximal Contractile integral;Distal Contractile integral;Contractile Front Velocity (cm/s);Onset velocity (between 11.0 & 3.0 above LES) (cm/s);Onset velocity (between 11.0 & 7.0 above LES) (cm/s);Onset velocity (between 7.0 & 3.0 above LES) (cm/s);Proximal maximal pressure duration time;Distal maximal pressure duration time;Wave duration (mean at 3.0 & 7.0 above LES) (sec);Wave duration (@11.0 above LES) (sec);Wave duration (@7.0 above LES) (sec);Wave duration (@3.0 above LES) (sec);Distal latency;Transmit time(s); | — |
Countries
China
Contacts
Public ContactXiaohua Hou
Outcome results
None listed