Study for the diagnosis and differential diagnosis of multiple system atrophy

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-DPC-15005941

Enrollment

Unknown

Registered

2015-01-25

Start date

2015-03-01

Completion date

Unknown

Last updated

2019-03-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple system atrophy

Interventions

Gold Standard:electrophysiological techniques

Index test:brain MRI

Eligibility

Sex/Gender

All

Age

30 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Male or female,30 years old to 80 years of age; 2. MSA patients are recruited meeting the diagnostic criteria by Gilman et al in 2008(Gilman S, Wenning GK, Low PA, et al.Second consensus statement on the diagnosis of multiple system atrophy. Neurology, 2008,71:670-676), while PD the diagnostic criteria by United Kingdom Parkinson's Disease Society brain bank (UKPDBB); 3. Disease duration is no less than 6 months; 4. Image control group(IC) consists of counterpart individuals with no organic brain disease.

Exclusion criteria

Exclusion criteria: 1. Exclusion criteria from Gilman's diagnostic criteria for MSA and UKPDBB's diagnostic criteria for PD; 2. Primary psychiatric disorders.3. Uncooperative conditions such as disorders of consciousness, severe cognitive impairment; 4. Severe dysfuction of liver, kidney, heart or multiple organ dysfunction; 5. Patients with heart pacemaker; 6. Metal objects in vivo which is contraindication for MRI; 7. Communication difficulties such as the deaf and the dumb; 8. Conditions unavailable for electrophysiological examination such as infection around the anus or the urethra; 9. Sphincter dysfunction presenting with voiding dysfunction or anal incontinence due to sacral cord lesions.

Design outcomes

Primary

Measure	Time frame
mean duration of motor unit action potientials;mean amplitude of motor unit action potientials;width of sylvian fissure;area of pons;area of forth ventricle;ratio between the maximum range of middle cerebellar peduncle and the length of corresponding prepontile cistern;percentage of polyphasic wave of motor unit action potientials;amplitude of strong contracting recruitment potientials;	—

Secondary

Measure	Time frame
sympathetic skin response;	—

Countries

China

Contacts

Public ContactQi Xiaokun

bjqxk@sina.com+86 13910797081

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026