beta-thalassemia major
Conditions
Interventions
Gold Standard:A normal MRI T2* liver is >6.3 ms. Mild liver iron overload was defined by MRI T2* between 2.7 ms and 6.3 ms. Moderate liver iron overload was defined by MRI T2* between 1.4 ms and 2.7 m
Index test:Nuclear 
Magnetic 
Sponsors
First Affilited Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
2 Years to 14 Years
Inclusion criteria
Inclusion criteria: Patients are diagnosed ß-thalassaemia major and will proceed allogeneic hematopoietic stem cell transplantation. All cases are in line with HLA matching high-resolution 10/10 matched, age from 2 to14 years old. Gender is not limited to a male/female.
Exclusion criteria
Exclusion criteria: 1. Patients with unstable vital sign or by other physiological or mental reasons can not undergo MRI exam; 2. Relatives of the patient refuse to join this research; 3. Patients with other diseases which can lead to iron overload; 4. Patients with other diseases in liver or heart(ie. neoplasms); 5. patients have inflamation, liver disease, heart failure or arrhythmia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum ferritin (SF);iron level of liver;iron level of Myocardium;ejection fraction; | — |
Countries
China
Contacts
Public ContactJianming Luo
Department of Pediatrics, The First Affiliated Hospital of Guangxi medical university
Outcome results
None listed