advanced hepatocellular carcinoma
Conditions
Interventions
Gold Standard:Clinical outcomes assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST)
Index test:Method: 
quantification 
of 
the 
contrast-enhanced 
ultrasound 
(CEUS)
Equipment: 
system 
America) 
equipped 
with 
a 
wideband 
C1-6 
Sponsors
1st Bethune Hospital, Jilin University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Clinically or histopathologically confirmed carcinoma; 2. With at least one measurable focus; 3. Chlid-pugh=7 scores; 4. Expectancy life span=3months ; 5. Major surgery after 3 months,local ablative techniques after 4 months,had not undergone anticancer chemotherapy within 2 weeks of study entry.
Exclusion criteria
Exclusion criteria: 1. Patients suffer from the medium or largeness fluid in the pleural or abdominal cavity and with clinical symptoms; 2. No severe heart, hepatosis and renal disfunction; 3. Ptients without written informed consent; 4. Pregnant and lactant women; 5. Patients had a history of ultrasound contrast agent hypersensitivity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to peak;Area under the curve;Peak intensity;Mean transit time;Overall survival (OS);Progression-free survival (PFS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Largest diameter of tumor;Echo type of tumor; | — |
Countries
China
Contacts
Public ContactDezhi Zhang
1st Bethune Hospital of Jilin University
Outcome results
None listed