Gastroesophageal reflux disease
Conditions
Interventions
Gold Standard:
Index test:
Sponsors
Xinqiao Hospital,the Third Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria were as follows: 1. Typical symptoms: regurgitation, heartburn, belching, chest pain, pharyngeal burning or foreign body sensation; 2. Atypical symptoms: chronic unexplained pharyngitis, hoarseness, bronchitis, asthma; 3. Proton pump inhibitor (PPI) therapy positive; 4. Aged between 18 and 65 years, Written informed consent
Exclusion criteria
Exclusion criteria: The inclusion criteria were as follows: Nasopharynx or upper esophagus obstruction; Esophageal varices and eophageal mucosal erosion; Severe esophageal motility disorder; In vivo with congenital gastrointestinal malformation, gastrointestinal obstruction, perforation, stricture or fistula; A recently history of stomach surgery,gastrointestinal bleeding (within the past six months); A history of bleeding tendency and taking anticoagulant drugs in long-term; Any implanted electrical device such as cardiac pacemakers; Allergy to the polymer materials; Various acute enteritis, severe ischemic disease and radioactive colitis; Pregnancy/lactation; Unstable cardiopathy, psychotic diseases, arrhythmia cordis, uncooperative.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| esophageal pH value;The incidence of adverse reactions;the rate of capsule detachment spontaneousl; | — |
Secondary
| Measure | Time frame |
|---|---|
| success rate of capsule attachment;Tolerance evaluation;Symptoms during the period of capsule attachment;Symptoms during the period of capsule monitoring;Modifications of daily activity, diet and sleep with pH capsule;acceptance evaluation; | — |
Countries
China
Contacts
Public ContactXiaoyan Zhao
Outcome results
None listed