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Comprehensive application of microRNA, proteomics and bioinformatics technology screen evaluation markers of the intestinal barrier injury and establish its evaluation criteria

Comprehensive application of microRNA, proteomics and bioinformatics technology screen evaluation markers of the intestinal barrier injury and establish its evaluation criteria

Status
Active, not recruiting
Phases
Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-DDT-09000503
Enrollment
Unknown
Registered
2009-08-17
Start date
2009-07-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute bowel obstruction

Interventions

Gold Standard:
Index test:

Sponsors

The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) The identification of patient's diagnosis was based on standard exam procedures (physical examination, ultrasonography, computed tomography scans, native X-ray exam) and/or a subsequent diagnostic laparotomy; (2) ability to read and understand the experiment, and to provide written informed consent.

Exclusion criteria

Exclusion criteria: (1) Gastrointestinal malignant tumor; (2) metabolic disease, such as diabetes mellitus (DM), gout, hyperlipoidemia (HL); (3) hematopathy, including all types of leukemia and anaemia; (4) any symptom of acute disease during the last 2 weeks, such as:febrile, cough, headache, nausea, vomit, stomachache, diarrhoea, hematuria; (5) momentous stress reaction during the last 2 weeks, such as psychic trauma and a large area of empyrosis; (6) use of speci?c drugs during the last 3 weeks, such as antibiotic (penicillins, quinolones, torlamician), hormone (deoxycortisone, dexamethasone), nonsteroid anti-in?ammatory drugs (NSAIDs; acenterine, fragrans, saridon, contac), among others; (7) medical treatments before current admission, such as radiotherapy, chemotherapy (because these treatments which invoke metabolic changes); (8) pregnant of lactating female.

Design outcomes

Primary

MeasureTime frame
different microRNA qRT -PCR;different protein qRT -PCR;different protein Western blot;

Contacts

Public ContactHuanlong Qin
huanlong_qin@live.cn+86 021 64361349

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026