ICH with bilateral pulmonary lesions
Conditions
Interventions
Gold Standard:The final clinical diagnosis is a comprehensive analysis of the results of conventional examination, the NGS, possible pathological detection and the change of treatment and response to
Index test:NGS detection
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. At the age of no less than 18; 2. Immunocompromised (details is as following); 3. Bilateral pulmonary military lesions, nodule-like lesions(<1cm), patch or patch-fusion lesions, or diffuse interstitial lesions can be found in imagological examination; And need etiological examination; 4. Inform the consent form. The Immunocompromised standard: 1. Neutropenia: count =500/ul (0.5*10^9/L). 1)Hematological malignancy2)Anticancer agent use3)Drug induced 2. Humoral immunodeficiency: ?-Globulin=500mg/dl(5g/l), Dysfunction of specific antibody production. Hematological malignancy; After splenectomy; Anti-CD20 antibody use; 3. Cellular immunodeficiency: In HIV patients, the CD4 count is=200/ul(0.2*10^9/L); Severity cannot be assessed by the CD4 count in the following: use of immunosuppressants; Use of anticancer agents; Hematological malignancy; Diabetes, renal failure; Use of biological preparations.
Exclusion criteria
Exclusion criteria: 1. With mental illness and can't complete the examination; 2. Taking part in other clinical trials that may affect this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the results of etiology detection; | — |
Countries
China
Contacts
Public ContactSong Yuanlin
Zhongshan Hospital, Fudan University
Outcome results
None listed