Dry Eye
Conditions
Interventions
Gold Standard:phenol red cotton
Index test:schirmer test strip
Sponsors
Eye Institute of Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Voluntary participation in this clinical study, and signed informed consent; 2. Male and female aged 18 ~ 70 years; 3. Clinical signs andsymptoms of dry eye,clinical examination in accordance with the "dry eye expert consensus" diagnostic criteria (as follows): (1) There is dryness, foreign body sensation, burning sensation, fatigue, discomfort, visual fluctuation of subjective symptoms andBUT of less than 5 seconds or Schirmer I test (without surface anesthesia) less than 5mm/5min; (2) There is dryness, foreign body sensation, burning sensation, fatigue, discomfort, visual fluctuation of subjective symptoms andBUT between 5 to 10s or 5 10s sec, Schirmer I test> 10mm / 5mm.;Inclusion criteria: 1. Voluntary participation in this clinical study, and signed informed consent; 2. Male and female aged 18 ~ 70 years; 3. Clinical signs andsymptoms of dry eye,clinical examination in accordance with the "dry eye expert consensus" diagnostic criteria (as follows): (1) There is dryness, foreign body sensation, burning sensation, fatigue, discomfort, visual fluctuation of subjective symptoms andBUT of less than 5 seconds or Schirmer I test (without surface anesthesia) less than 5mm/5min; (2) There is dryness, foreign body sensation, burning sensation, fatigue, discomfort, visual fluctuation of subjective symptoms andBUT between 5 to 10s or 5 10s sec, Schirmer I test> 10mm / 5mm.;Inclusion criteria: 1. Voluntary participation in this clinical study, and signed informed consent; 2. Male and female aged 18 ~ 70 years; 3. Clinical signs andsymptoms of dry eye,clinical examination in accordance with the "dry eye expert consensus" diagnostic criteria (as follows): (1) There is dryness, foreign body sensation, burning sensation, fatigue, discomfort, visual fluctuation of subjective symptoms andBUT of less than 5 seconds or Schirmer I test (without surface anesthesia) less than 5mm/5min; (2) There is dryness, foreign body sensation, burning sensation, fatigue, discomfort, visual fluctuation of subjective symptoms andBUT between 5 to 10s or 5 10s sec, Schirmer I test> 10mm / 5mm.;Inclusion criteria: 1. Voluntary participation in this clinical study, and signed informed consent; 2. Male and female aged 18 ~ 70 years; 3. Clinical signs andsymptoms of dry eye,clinical examination in accordance with the "dry eye expert consensus" diagnostic criteria (as follows): (1) There is dryness, foreign body sensation, burning sensation, fatigue, discomfort, visual fluctuation of subjective symptoms andBUT of less than 5 seconds or Schirmer I test (without surface anesthesia) less than 5mm/5min; (2) There is dryness, foreign body sensation, burning sensation, fatigue, discomfort, visual fluctuation of subjective symptoms andBUT between 5 to 10s or 5 10s sec, Schirmer I test> 10mm / 5mm.;Inclusion criteria: 1. Voluntary participation in this clinical study, and signed informed consent; 2. Male and female aged 18 ~ 70 years; 3. Clinical signs andsymptoms of dry eye,clinical examination in accordance with the "dry eye expert consensus" diagnostic criteria (as follows): (1) There is dryness, foreign body sensation, burning sensation, fatigue, discomfort, visual fluctuation of subjective symptoms andBUT of less than 5 seconds or Schirmer I test (without surface anesthesia) less than 5mm/5min; (2) There is dryness, foreign body sensation, burning sensation, fatigue, discomfort, visual fluctuation of subjective symptoms andBUT between 5 to 10s or 5 10s sec, Schirmer I test> 10mm / 5mm.
Exclusion criteria
Exclusion criteria: 1. limbal stem cell abnormalities or other causes of ocular surface diseases, such as chemical injuries, thermal burns; 2. Fungal,bacterial or viral keratoconjunctivitis; 3. Combine with other conjunctival, corneal and iris lesions; 4. Have eye surgery or eye injury within 6 months; 5. hormone replacement therapy; 6. Systemic diseases and other eye diseases that affect the evaluation of efficacy; 7. Severe dry eye or filamentary keratitis; 8. The recent use of eye drop treatment; 9. According to the judgment of the doctors that it is not suitable in the study.;Exclusion criteria: 1. limbal stem cell abnormalities or other causes of ocular surface diseases, such as chemical injuries, thermal burns; 2. Fungal,bacterial or viral keratoconjunctivitis; 3. Combine with other conjunctival, corneal and iris lesions; 4. Have eye surgery or eye injury within 6 months; 5. hormone replacement therapy; 6. Systemic diseases and other eye diseases that affect the evaluation of efficacy; 7. Severe dry eye or filamentary keratitis; 8. The recent use of eye drop treatment; 9. According to the judgment of the doctors that it is not suitable in the study.;Exclusion criteria: 1. limbal stem cell abnormalities or other causes of ocular surface diseases, such as chemical injuries, thermal burns; 2. Fungal,bacterial or viral keratoconjunctivitis; 3. Combine with other conjunctival, corneal and iris lesions; 4. Have eye surgery or eye injury within 6 months; 5. hormone replacement therapy; 6. Systemic diseases and other eye diseases that affect the evaluation of efficacy; 7. Severe dry eye or filamentary keratitis; 8. The recent use of eye drop treatment; 9. According to the judgment of the doctors that it is not suitable in the study.;Exclusion criteria: 1. limbal stem cell abnormalities or other causes of ocular surface diseases, such as chemical injuries, thermal burns; 2. Fungal,bacterial or viral keratoconjunctivitis; 3. Combine with other conjunctival, corneal and iris lesions; 4. Have eye surgery or eye injury within 6 months; 5. hormone replacement therapy; 6. Systemic diseases and other eye diseases that affect the evaluation of efficacy; 7. Severe dry eye or filamentary keratitis; 8. The recent use of eye drop treatment; 9. According to the judgment of the doctors that it is not suitable in the study.;Exclusion criteria: 1. limbal stem cell abnormalities or other causes of ocular surface diseases, such as chemical injuries, thermal burns; 2. Fungal,bacterial or viral keratoconjunctivitis; 3. Combine with other conjunctival, corneal and iris lesions; 4. Have eye surgery or eye injury within 6 months; 5. hormone replacement therapy; 6. Systemic diseases and other eye diseases that affect the evaluation of efficacy; 7. Severe dry eye or filamentary keratitis; 8. The recent use of eye drop treatment; 9. According to the judgment of the doctors that it is not suitable in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tear Production;TBUT;Schirmer Test;Corneal staining scores;Conjunctival staining scores;conjunctival congestion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Irritation score; | — |
Countries
China
Contacts
Public ContactZuguo Liu;Zuguo Liu;Zuguo Liu;Zuguo Liu;Zuguo Liu ;;;;
Eye Institute of Xiamen University;Eye Institute of Xiamen University;Eye Institute of Xiamen University;Eye Institute of Xiamen University;Eye Institute of Xiamen University
Outcome results
None listed