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Early detection of lung cancer using circulating tumor DNA methylation by targeted bisulfite sequencing

The applied research of precise diagnosis and therapy in lung cancer

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-DDD-17012123
Enrollment
Unknown
Registered
2017-07-25
Start date
2015-12-01
Completion date
Unknown
Last updated
2017-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

ctDNA
Gold Standard:Pathological diagnosis, including HE staining and immunohistochemistry
Index test:Methylation&#32
signature&#32
in&#32

Sponsors

West China Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Older than or equal to 18 years old; 2. Chest CT or LDCT positive pulmonary nodules; 3. All patients should be subjected to surgical resection of their pulmonary nodules; 4. Participate in this study voluntarily.

Exclusion criteria

Exclusion criteria: Without a definitive diagnosis of lung nodule after surgery.

Design outcomes

Primary

MeasureTime frame
sensitivity;specificity;ACC;Power of diagnosis;—

Secondary

MeasureTime frame
positive predictive value;negative predictive value;—

Countries

China

Contacts

Public ContactLi Weimin

West China Hospital, Sichuan University

weimin003@163.com+86 18980601009

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026