POCD
Conditions
Interventions
Gold Standard:neurocognitive test
Index test:CT, 
MR, 
factor, 
S100, 
GFAP
Sponsors
Shanghai Tongji Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients had to be >=65 years of age and ASA physical health class I to III, who were receiving elective laparoscopic surgery lower extremity/abdominal surgery.The operation time must between 2 to 6 hours.No narcotic drug allergy; no serious liver and kidney dysfunction; no severe anemia; no previous history of cardiovascular disease or related surgery; no neurological or psychiatric diseases; no long-term continuous use of antipsychotic drugs or antidepressants history; no alcoholism or drug abuse: no hearing and speech disorder; The patients or their clients must understand the study and sign their names on the document.
Exclusion criteria
Exclusion criteria: During the perioperative period, patients who did not participate in neuropsychological test or MRI examination, intraoperative blood loss (>1000ml), mean arterial pressure (MAP<60mmHg) during operation, postoperative cerebral embolism, cerebral hemorrhage, pulmonary infection and other severe complications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| neuroconitive test;Inflammatory factor;CT cerebral perfusion;MR; | — |
Countries
China
Contacts
Public ContactLiu Jianhui
Shanghai Tongji Hospital
Outcome results
None listed