Tourette syndrome
Conditions
Interventions
Gold Standard:
Index test:
Sponsors
Second Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
11 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Patients with TS: (1) age between 18 to 25 years; (2) History meet the criterion of American Diagnostic and Statistical Manual of Mental Disorders fourth Edition ( DSM-IV-TR ); (3) A total of 20 patients (Men and women each have 10 people); 2. Healthy volunteers (The data have been acquired in previous clinical study, which was proved by ethical review and recorded in Chinese Clinical Trial Registry. Registration number: ChiCTR-OCC-09000358): Men and women each have 5 people; 3. No history of physical, especially brain organic disease, and no history of substance use including analgesics, antiepileptics and antipsychotic. Patients of TS do not have other disease; 4. No other serious concomitant diseases; 5. Willing and able to follow the program during the study period; 6. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of allergies to Contrast agents or tracers; 2. Having received any experimental drugs or protocols in half a year before entering the group , that is, having participated in another experiment; 3. Current or past use of addictive drugs, analgesics, antiepileptics and antipsychotic; 4. Current or planned pregnancy; 5. Subjects receivied major surgery within 1 year before entering the group, or not yet fully recovered from the effects of major surgery; 6. Claustrophobic patients 7. Unwilling and unable to follow the program during the study period; 8. Current or past mood disorder, anxiety disorder, psychotic disorder, or mental retardation based on DSM-IV criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Function of dopamine receptor;Function of 5-HT receptor; | — |
Countries
China
Contacts
Public ContactJianhua Feng
Outcome results
None listed