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Mechanism Research on Parturient's Permanent Nerve Injury Caused by Intraspinal Anesthesia

Mechanism Research on Parturient's Permanent Nerve Injury Caused by Intraspinal Anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-CRC-17012772
Enrollment
Unknown
Registered
2017-09-22
Start date
2012-01-01
Completion date
Unknown
Last updated
2017-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nerve Injury

Interventions

Experiment Group:Not Applicable

Sponsors

Guangzhou Women and Children's Medical Center
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Inclusion Standards for Experiment Group: 1. The primipara who accepted combined spinal epidural anesthesia in the cesarean section, while felt abnormal dyskinesia in pelvic floor perineal region and lower limbs after the operation; 2. The parturient who was explicitly diagnosed to have anesthesia-causing nerve injuries based on group consultation results of relevant departments of over three tertiary A hospitals; 3. Systematic and regular neural rehabilitation failed over half a year; 4. Nerve injury symptoms aggravated or did not get better obviously during the over 3 years of following-up. Inclusion Standards for Control Group: 1. The primipara who accepted combined spinal epidural anesthesia in the cesarean section, while did not feel any abnormal dyskinesia after the operation; 2. During the 3 years of following-up parallel to the experiment group, no relevant nerve injury symptom was found.;Inclusion criteria: Inclusion Standards for Experiment Group: 1. The primipara who accepted combined spinal epidural anesthesia in the cesarean section, while felt abnormal dyskinesia in pelvic floor perineal region and lower limbs after the operation; 2. The parturient who was explicitly diagnosed to have anesthesia-causing nerve injuries based on group consultation results of relevant departments of over three tertiary A hospitals; 3. Systematic and regular neural rehabilitation failed over half a year; 4. Nerve injury symptoms aggravated or did not get better obviously during the over 3 years of following-up. Inclusion Standards for Control Group: 1. The primipara who accepted combined spinal epidural anesthesia in the cesarean section, while did not feel any abnormal dyskinesia after the operation; 2. During the 3 years of following-up parallel to the experiment group, no relevant nerve injury symptom was found.;Inclusion criteria: Inclusion Standards for Experiment Group: 1. The primipara who accepted combined spinal epidural anesthesia in the cesarean section, while felt abnormal dyskinesia in pelvic floor perineal region and lower limbs after the operation; 2. The parturient who was explicitly diagnosed to have anesthesia-causing nerve injuries based on group consultation results of relevant departments of over three tertiary A hospitals; 3. Systematic and regular neural rehabilitation failed over half a year; 4. Nerve injury symptoms aggravated or did not get better obviously during the over 3 years of following-up. Inclusion Standards for Control Group: 1. The primipara who accepted combined spinal epidural anesthesia in the cesarean section, while did not feel any abnormal dyskinesia after the operation; 2. During the 3 years of following-up parallel to the experiment group, no relevant nerve injury symptom was found.;Inclusion criteria: Inclusion Standards for Experiment Group: 1. The primipara who accepted combined spinal epidural anesthesia in the cesarean section, while felt abnormal dyskinesia in pelvic floor perineal region and lower limbs after the operation; 2. The parturient who was explicitly diagnosed to have anesthesia-causing nerve injuries based on group consultation results of relevant departments of over three tertiary A hospitals; 3. Systematic and regular neural rehabilitation failed over half a year; 4. Nerve injury symptoms aggravated or did not get better obviously during the over 3 years of following-up. Inclusion Standards for Control Group: 1. The primipara who accepted combined spinal epidural anesthesia in the cesarean section, while did not feel any abnormal dyskinesia after the operation; 2. During the 3 years of following-up parallel to the experiment group, no relevant nerve injury symptom was found.;Inclusion criteria: Inclusion Standards for Experiment Group: 1. The primipara who accepted combined spinal epidural anesthesia in the cesarean section, while felt abnormal dyskinesia in pelvic floor perineal region and lower limbs after the operation; 2. The parturient who was explicitly diagnosed to have anesthesia-causing nerve injuries based on group consultation results of relevant departments of over three tertiary A hospitals; 3. Systematic and regular neural rehabilitation failed over half a year; 4. Nerve injury symptoms aggravated or did not get better obviously during the over 3 years of following-up. Inclusion Standards for Control Group: 1. The primipara who accepted combined spinal epidural anesthesia in the cesarean section, while did not feel any abnormal dyskinesia after the operation; 2. During the 3 years of following-up parallel to the experiment group, no relevant nerve injury symptom was found.

Exclusion criteria

Exclusion criteria: Exclusion Standards for Experiment Group: 1. Abnormal dyskinesia was felt in pelvic floor perineal region and lower limbs after the operation, while symptoms disappear after treatments of less than 2 weeks; 2. Nerve injury symptoms were improved gradually through over half a year of systematic and regular neural rehabilitation treatment; 3. The case was expulsed within 3 years of following-up. Inclusion Standards for Control Group: Tardive nerve injury symptoms were found within the 3 years of following-up parallel to the experiment group. ;Exclusion criteria: Exclusion Standards for Experiment Group: 1. Abnormal dyskinesia was felt in pelvic floor perineal region and lower limbs after the operation, while symptoms disappear after treatments of less than 2 weeks; 2. Nerve injury symptoms were improved gradually through over half a year of systematic and regular neural rehabilitation treatment; 3. The case was expulsed within 3 years of following-up. Inclusion Standards for Control Group: Tardive nerve injury symptoms were found within the 3 years of following-up parallel to the experiment group. ;Exclusion criteria: Exclusion Standards for Experiment Group: 1. Abnormal dyskinesia was felt in pelvic floor perineal region and lower limbs after the operation, while symptoms disappear after treatments of less than 2 weeks; 2. Nerve injury symptoms were improved gradually through over half a year of systematic and regular neural rehabilitation treatment; 3. The case was expulsed within 3 years of following-up. Inclusion Standards for Control Group: Tardive nerve injury symptoms were found within the 3 years of following-up parallel to the experiment group. ;Exclusion criteria: Exclusion Standards for Experiment Group: 1. Abnormal dyskinesia was felt in pelvic floor perineal region and lower limbs after the operation, while symptoms disappear after treatments of less than 2 weeks; 2. Nerve injury symptoms were improved gradually through over half a year of systematic and regular neural rehabilitation treatment; 3. The case was expulsed within 3 years of following-up. Inclusion Standards for Control Group: Tardive nerve injury symptoms were found within the 3 years of following-up parallel to the experiment group. ;Exclusion criteria: Exclusion Standards for Experiment Group: 1. Abnormal dyskinesia was felt in pelvic floor perineal region and lower limbs after the operation, while symptoms disappear after treatments of less than 2 weeks; 2. Nerve injury symptoms were improved gradually through over half a year of systematic and regular neural rehabilitation treatment; 3. The case was expulsed within 3 years of following-up. Inclusion Standards for Control Group: Tardive nerve injury symptoms were found within the 3 years of following-up parallel to the experiment group.

Design outcomes

Primary

MeasureTime frame
circRNA;lncRNA;mRNA;

Countries

China

Contacts

Public ContactXingrong Song;Xingrong Song;Xingrong Song;Xingrong Song;Xingrong Song ;;;;

Guangzhou Women and Children's Medical Center;Guangzhou Women and Children's Medical Center;Guangzhou Women and Children's Medical Center;Guangzhou Women and Children's Medical Center;Guangzhou Women and Children's Medical Center

songxingrong510623@163.com;songxingrong510623@163.com;songxingrong510623@163.com;songxingrong510623@163.com;songxingrong510623@163.com+86 13924416303;+86 13924416303;+86 13924416303;+86 13924416303;+86 13924416303

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026