acne vulgaris
Conditions
Interventions
Acne vulgaris patients:samples will be obtained by non-invasive methods from follicles and comedones for analysis
healthy individuals:samples will be obtained by non-invasive methods from follicles for analysis
Patients of skin excision surgicals:Viable skin samples excised by surgical operations, and are to be disposed of, will be obtained by us for further studies under permission of the patients
Acne vulgaris patients:corneum plugs will be obtained by non-invasive methods from comedones for analysis
Acne vulgaris patients:a punch biopsy will be obtained from one comedonal lesion for in vitro studies
Sponsors
Shanghai Skin Disease Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Male or female mild to moderate acne vulgaris patients aged 18-40, untreated by any drugs/medicine or methods during the past 2 weeks before involvement in this study. In control groups and normal healthy individual groups, healthy volunteers will be recruited.
Exclusion criteria
Exclusion criteria: (1) Patients with severe systematic diseases and other skin diseases, pregnant and lactating women, persons incapable of disposing; (2) Individuals who have been intervened by any medical methods or drugs in the past 2 weeks before involvement in the study, and who are using color cosmetics which may interfere our observation; (3) Persons with severe skin barrier disorder; (4) Patients with rosacea, perioral dermatitis, sensitive skins, seborrheic dermatitis, Gram- bacterial folliculitis and other pilo-sebaceous unit related skin diseases that mimic acne; (5) Patients of other acne types, such as acne fulminans, hidradenitis suppurativa, chloracne; (6) Patients of endocrinal diseases, such as SAPPHO syndrome, PCOS, and adrenal hyperplasia syndrome etc.; (7) Individuals of keloid predisposition and allergic and/or atopic characteristics (such as urticaria); (8) Individuals who are taking steroidal medicine/drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| microflora diversity;UV-induced fluoresence of sebum, sebaceous glands, corneum plugs and/or follicles;Spatial distribution of microorganisms in acne lesions;Potential of various related microorganisms in impact on skin cells and capabilities in induction of acne lesions in artificial skin models and/or animal models; | — |
Countries
China
Contacts
Public ContactDetian Xu
Shanghai Skin Disease Hospital
Outcome results
None listed