skin allergy caused by Chinese medicine injection
Conditions
Interventions
group 1:Injection with salvia miltiorrhiza phenolic acids more clinical intended use method is: 100 mg, 250 ml, 0.9% sodium chloride injection by intravenous infusion after dissolving, the clinical in
group 2:Lactones ginkgo biloba injection clinical intended use method is: 10 ml (50 mg), 250 ml0. 9% sodium chloride injection by intravenous infusion after dissolving, the clinical infusion concentra
group 3:Ginkgo diterpene lactone meglumine injection clinical intended use method is: 5 ml (including gingko diterpene lactone 25 mg), 250 ml0. 9% sodium chloride injection by intravenous infusion aft
Sponsors
The second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years old, male and female; 2. Meet one of the following conditions: Group 1: never use any salvia miltiorrhiza agents (including injection with salvia miltiorrhiza polyphenols acid); Ever use salvia miltiorrhiza agents (including injection with salvia miltiorrhiza phenolic acids), not happened allergic reaction;Ever use salvia miltiorrhiza agents (including injection with salvia miltiorrhiza phenolic acids), had an allergic reaction;There was a drug allergy reaction;And voluntary informed consent to participate in the subjects. Group 2: never use any ginkgo lactone, lactones ginkgo, ginkgo lactone B, ginkgo lactone C preparation (including lactones ginkgo biloba injection);Used any ginkgo lactone, lactones ginkgo, ginkgo lactone B, ginkgo lactone C preparation (including lactones ginkgo biloba injection), not happened allergic reaction; Ever use any ginkgo lactone, lactones ginkgo, ginkgo lactone B, ginkgo lactone C preparation (including lactones ginkgo biloba injection), allergic reaction has occurred;There was a drug allergy reaction; And voluntary informed consent to participate in the subjects. Group 3: never use any ginkgo lactone, lactones ginkgo, ginkgo lactone B, ginkgo lactone K preparations (including ginkgo diterpene lactone meglumine injection); Used any ginkgo lactone, lactones ginkgo, ginkgo lactone B, ginkgo lactone K preparations (including ginkgo diterpene lactone meglumine injection), not happened allergic reaction; Ever use any ginkgo lactone, lactones ginkgo, ginkgo lactone B, ginkgo lactone K preparations (including lactones ginkgo biloba injection), allergic reaction has occurred; There was a other drug allergy reaction;And voluntary informed consent to participate in the subjects.
Exclusion criteria
Exclusion criteria: 1. Women who during pregnancy, or lactation,or menstrual; 2. To have an infectious disease, eczema, dermatitis or trauma and infection; 3. In one of the following conditions: two days to use a beta blocker adrenaline; one week used H1 antihistamines, imipramine, phenothiazine, beta adrenergic drugs ; one week used short-term sugar cortical hormone drugs; Local used two weeks of glucocorticoid hormone drugs; Four weeks used long-term glucocorticoid hormone drugs. 4. According to the researchers determine other unfavorable into groups.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Different concentrations for injection salvia miltiorrhiza polyphenols acid after skin prick/intradermal test appear allergic reaction rate and the composition of all kinds of positive reaction; | — |
Countries
China
Contacts
Public ContactYanfen Li
Outcome results
None listed