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Epigentic susceptibility mechanisms of postoperative cognitive dysfunction

The role of GR gene methylation associated with inflammation disregulation on epigentic susceptibility mediated POCD development

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-COC-17011332
Enrollment
Unknown
Registered
2017-05-08
Start date
2017-05-20
Completion date
Unknown
Last updated
2017-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative cognitive dysfunction

Interventions

Case series:Nil

Sponsors

Xuzhou Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 75 Years

Inclusion criteria

Inclusion criteria: Eligible subjects were ASA I or II patients between 65 and 75 years of age, scheduled for total knee arthroplasty or hip replacement.

Exclusion criteria

Exclusion criteria: Mini-Mental State Examination (MMSE) score35; patients on analgesics or antidepressants; inability to comply with the study protocol or procedures.

Design outcomes

Primary

MeasureTime frame
Postoperative cognitive function;Glucocorticoid receptor level;levels of glucocorticoid receptor gene methylation;plasma levels of pro-inflammatory cytokines;other outcome according to the experimental instances;—

Countries

China

Contacts

Public ContactLiwei Wang

Xuzhou Central Hospital

doctorlww@sina.com+86 18952170255

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026