chronic hepatitis C
Conditions
Interventions
Control:no
HCV (F<2):no
HCV (2):no
HCV-HCC:no
Sponsors
The Third Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Baseline biopsy are consistent with the diagnosis of CHC; 2. Baseline CT/MRI are consistent with diagonosis of HCC; 3. Compensated liver diseases (Child-Pugh: A).
Exclusion criteria
Exclusion criteria: 1. History or other evidence of decompensated liver disease (Coagulopathy, hyperbilirubinemia, hepatic encephalopathy, hypo-albuminemia, ascites, and bleeding from esophageal varices are conditions consistent with decompensated liver disease; patients with cirrhosis in Child-Pugh score > 6); 2. Co-infection with active hepatitis B, hepatitis D and/or human immuno- deficiency virus (HIV); 3. Neutrophil count 100 ng/mL; 5. Pregnant or breast-feeding females (positive pregnancy test immediately prior to initiation of therapy), male partners of women who are to be pregnant; 6. Serum creatinine level > 1.5 ULN at screening; 7. History of drug allergy on IFN or any compound of IFN; 8. History of drug and alcohol abuse; 9. History of autoimmune disease; History of severe psychiatric disease, especially depression; History of thyroid disease poorly controlled on prescribed medications; History of severe retinal disease; History of malignant tumor; History of chronic pulmonary disease with insufficient function; History of severe cardiac or digestive disease; History of disease aggravating anaemia; 10. Other issues that investigators consider unsuitable for this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ALT;AST; | — |
Countries
China
Contacts
Public ContactYuemin Nan
Third Hospital of HeiBei Medical University
Outcome results
None listed