primary ovarian insufficiency
Conditions
Interventions
POI group:Detection of methylation status of partial genes
the postmenopausal group:Detection of methylation status of partial genes
the normal control group:Detection of methylation status of partial genes
Sponsors
The First Affiliated Hospital of Xi'an Jiao Tong University
Eligibility
Sex/Gender
Female
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Using the international POI, menopause diagnostic criteria and normal menstrual cycle women assessment indicators. 1.POI group: (1) women aged less than 40 years; (2) the time more than 4 months of amenorrhea; (3) serum follicle stimulating hormone (FSH) 2 times or more than 2 times > 40mIU/ml (two times of examination interval 1 month or more), estradiol (E2) 40mIU/mL, E2 =3ng/mL; (4) for tubal or male factors, treatment of infertility patients; (5) exclude contraindications.
Exclusion criteria
Exclusion criteria: Exclusion criteria: (1) because of the hypothalamus and pituitary disorders in patients with amenorrhea; (2) patients with ovarian insufficiency due to chemotherapy and specific drug induced; (3) ovarian insufficiency patients caused by the history of surgery with ovarian or bilateral oophorectomy; (4) chromosome 46, XY pseudohermaphrodism patients; (5) in patients with malignant tumor; (6) combined with severe cardiovascular disease, cerebrovascular disease, liver and kidney diseases and hematopoietic system of patients with serious diseases, and other serious mental illness or unstable body disease; (7) combined with severe endocrine and metabolic diseases: such as diabetes, systemic lupus erythematosus, rheumatoid arthritis, congenital adrenal hyperplasia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| methylation status of partial genes; | — |
Countries
China
Contacts
Public ContactShulan Lv
The First Affiliated Hospital of Xi'an Jiao Tong University
Outcome results
None listed