globus
Conditions
Interventions
the globus group :N/A
the control group :N/A
Sponsors
Guangzhou First Municipal People's Hospital, Guangzhou Nan Sha Center Hospital Affiliated to Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Outpatients with globus from the department of gastroenterology of Guangzhou First Municipal People's Hospital, Nansha Central Hospital of Guangzhou First Municipal People's Hospital; 2. The diagnosis of globus meets the Rome III criteria for globus, including all of the follows: 2.1 Persistent or intermittent, nonpainful sensationof a lump or foreign body in the throat; 2.2 Occurrence of the sensation between meals; 2.3 Absence of dysphagia or odynophagia; 2.4 Absence of evidence that gastroesophageal refluxis the cause of the symptom; 2.5 Absence of histopathology-based esophagealmotility disorders. Criteria fulfilled for the last 3 months with symptom onsetat least 6 months before diagnosis. 3. Nasal laryngoscopy, endoscopy and blood biochemical examination are required for all the patients to exclude organic disease of larynx and esophagus(such as parapharyngeal tumors, cysts epiglottis, hypopharynx cancer, esophageal cancer etc.), thyroid disease, connective tissue disease, nerve system diseases and mental illness; 4. Signed informed consent and agreed to enter the study.The criteriaof control group: ages from 18 to 70 years old; has no hysterical ball disease symptoms (pharyngeal foreign body sensation, phlegm, swelling, etc.); No acid reflux, heartburn, bloating or other diseases of the digestive system performance; nasal pharyngeal and esophageal cancer of the throat and esophagus organic disease, cardiac failure delays, GERD, systemic sclerosis, and thyroid dysfunctione that has not been found tangible evidenc by laryngoscope, gastroscope, blood biochemical examination pharyngitis.
Exclusion criteria
Exclusion criteria: 1. Patients do not meet the diagnostic criteria of globus; 2. Patients with organic diseases of larynx and esophagus detected by nasal laryngoscopy, endoscopy and blood biochemical examination; 3. Patients accompanying thyroid diseases; 4. Patients accompanying neurological diseases and mental illness; 5. patients do not cooperate with the investigation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serotonin transporter SLC6A4 genotype;catechol-O-methyltransferase Val158Met genotype; | — |
Countries
China
Contacts
Public ContactLin Jia
Outcome results
None listed