Respiratory distress syndrome in preterm infants
Conditions
Interventions
The case group:SNP detection
The control group:SNP detection
Sponsors
Linyi People's Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 1 Years
Inclusion criteria
Inclusion criteria: The diagnosis was made in accordance with European consensus guidelines on the management of neonatal respiratory distress syndrome (NRDS) in preterm infants, specifically: (1) the cases began progressive dyspnea within 12 h after birth; (2) PaO2 50 mmHg; (3) chest X-ray indicated the specific performances like ground-glass opacity, air bronchogram and white lung. Another 204 preterm infants born during the same period with similar gestational age and birth weight and with no obvious symptoms of infection were recruited as the control group. Inclusion criteria for the control group: (1) chest X-ray showed no signs of NRDS or pulmonary infection; (2) blood routine and C-reaction protein (CRP) showed no clear signs of infection.
Exclusion criteria
Exclusion criteria: Exclusion criteria for both the case and control group: (1) the cases with severe congenital disease, such as complex congenital heart disease, diaphragmatic hernia, cerebral dysplasia; (2) the cases with genetic metabolic diseases, such as phenylketonuria, congenital hypothyroidism and diabetes; (3) the cases with a clear infection in the late pregnancy and the IgM of the neonatal cases increased.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SNP genotype; | — |
Secondary
| Measure | Time frame |
|---|---|
| Protein level; | — |
Countries
China
Contacts
Public ContactTang Hui
Department of Pediatrics, Linyi People's Hospital
Outcome results
None listed